HTTP Error 500.21 - Internal Server Error Handler "ExtensionlessUrlHandler-Integrated-4.0" has a bad module "ManagedPipelineHandler" in its module list.

Problem: The Kaseya VSA gives the below message when trying to login: 

Cause: This usually happens when the .NET Framework on the Kaseya Server has issues or has been removed.

Resolution/Workaround: Run this command via cmd as Admin and it should fix the issue: c:\Windows\Microsoft.NET\Framework64\v4.0.30319\aspnet_regiis.exe -I

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